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Joint CMU-Pitt Ph.D. Program in Computational Biology
Robert F. Murphy and Ivet Bahar, Directors
Computational Structural Biology Specialization Area
Computational Structural Biology aims at establishing biomolecular sequence-structure-function relations using fundamental principles of physical sciences in theoretical models and simulations of structure and dynamics. After the advances in complete genomes sequencing, it became evident that structural information is needed for understanding the origin and mechanisms of biological interactions, and designing/controlling function. Computational Structural Biology emerged as a tool for efficient identification of structure and dynamics in many applications. Major research topics include protein folding, protein dynamics with emphasis on large complexes and assemblies, protein-protein, protein-ligand and protein-DNA interactions and their functional implications. Drug design and protein engineering represent applications of note.
Required Life Sciences Elective (one of the following)
| Pitt MSMBPH-2001 | Molecular Biophysics I |
| Pitt BIOSC 2810 | Macromolecular Structure and Function |
Required Quantitative Elective (one of the following)
| Pitt BIOST 2043 | Intro to Statistical Theory |
| Pitt BIOST 2063 | Bayesian and Empirical Bayes Statistical Methods |
| Pitt MATH 2370 | Matrices and Linear Operators (Linear Algebra) |
| Pitt MATH 2030 | Iterative Methods for Linear Systems |
| Pitt MATH 2070 | Numerical Methods in Scientific Computing |
| Pitt MATH 2090 | Numerical Solution of Ordinary Differential Equations |
| Pitt STAT 2631 | Theory of Statistics |
| Pitt STAT 2711 | Probability Theory I |
| CMU 10-708 | Probabilistic Graphical Models |
| CMU 15-750 | Algorithms |
| CMU 15-859G | Computational Geometry |
| CMU 36-625 | Probability and Mathematical Statistics I |
| CMU 36-753/754 | Probability Theory and Stochastic Process |
Specialization Electives (two in total)
At least one of the following two classes:
| CMU 15-879A | Algorithms for Computational Structural Biology |
| Pitt MSCBIO 2035 | Computational Structural Biology II |
| CMU 15-873A | Advanced Topics in Computational Structural Biology |
| CMU 33-765 | Statistical Mechanics |
| Pitt CHE 2754 | Principles of Polymer Engineering |
| Pitt CHEM 2430 | Quantum Mechanics and Kinetics |
| Pitt CHEM 2440 | Thermodynamics & Statistical Mechanics |
| Pitt CHEM 3430 | Introduction to Modern Computational Chemistry |
| Pitt CHEM 3450 | Molecular Modeling and Graphics |
| Pitt MSMPHL 2310 | Principles of Pharmacology |
| Pitt MSMPHL 2370 | Drug Discovery |
| Pitt MSMPHL 3360 | Molecular Pharmacology |
| Pitt PHYS 2274 | Computational Physics |
| Pitt PHYS 2541 | Statistical Physics |
| CMU 09-560 | Molecular Modeling and Computational Chemistry |
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